Atletico's preparations ahead of their 14th match in three seasons against Real Madrid in the champions league have been badly hit by injuries.
Atletico will play their derby rivals without three defenders - Uruguay centre-back Jose Gimenez (groin), former Real right-back Juanfran (thigh) and Croatia full-back Sime Vrsaljko (hip).
Belgium winger Yannick Carrasco is doubtful with a collarbone injury.
Atletico boss Diego Simeone said he was confident his side would produce a performance to make him proud whatever team he put out.
"I never tire of praising these players, they are incredible," he added.
Atletico, who are third in the table, have taken just one point off Real in two league games this season.